Postgraduate molecular biology course – 2023
Posgrado en Ciencias Biomédicas Básicas
Facultad de Medicina, Universidad Autónoma de San Luis Potosí.
From October 2nd, 2023 to January 19th, 2024.
Semester: 1st semester
Type: Theoretical.
Total allocated time: 60 hours
Number of credits: 7.5
Schedule: Mondays, Wednesdays and Fridays from 11:30 to 13:00
Syllabus:
1. History and timeline of relevant events in genetics and molecular biology.
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2. Biochemistry of nucleic acids.
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3. Organisation and condensation of nucleic acids.
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4. Genomes.
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5. Chromosomes.
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6. Nucleosome and epigenetics.
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7. Genes, alleles and haplotypes.
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8. The replicon, plasmids and bacterial cell division.
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9. Prokaryote and eukaryote Replication.
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10. DNA Repair defects and its diseases.
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11. Prokaryote transcription.
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12. Eukaryote transcription.
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13. mRNA, tRNA and mRNA
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14. RNA interference
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15. The genetic code
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16. Translation in prokaryotes and eukaryotes
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17. Protein localization
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18. Chaperones
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19. Transposons
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20. Retroposons & retrovirus
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21. Molecular techniques
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22. Pharmacogenomics
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Reference texts:
Molecular Biology of the Cell. 4th edition.
Alberts B, Johnson A, Lewis J, et al.
New York: Garland Science; 2002.
Freely available through NCBI.
Molecular Cell Biology. 4th edition.
Lodish H, Berk A, Zipursky SL, et al.
New York: W. H. Freeman; 2000.
Freely available through NCBI.
Genomes, 2nd edition
Terence A Brown.
Department of Biomolecular Sciences, UMIST, Manchester, UK
Oxford: Wiley-Liss; 2002.
Freely available through NCBI.
Supplementary literature:
Arnott S.
Historical article: DNA polymorphism and the early history of the double helix.
Trends Biochem Sci. 2006 Jun;31(6):349-54.
Zlatanova J, Leuba SH.
Stretching and imaging single DNA molecules and chromatin.
J Muscle Res Cell Motil. 2002;23(5-6):377-95.
Langston LD, O'Donnell M.
DNA replication: keep moving and don't mind the gap.
Mol Cell. 2006 Jul 21;23(2):155-60.
Martin AM, Freitas EM, Witt CS, Christiansen FT.
The genomic organization and evolution of the natural killer immunoglobulin-like receptor (KIR) gene cluster.
Immunogenetics. 2000 Apr;51(4-5):268-80.
Sonoda E, Takata M, Yamashita YM, Morrison C, Takeda S.
Homologous DNA recombination in vertebrate cells.
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8388-94.
Crow JF.
Spontaneous mutation in man.
Mutat Res. 1999 Jul;437(1):5-9.
Lawrence JG.
Shared strategies in gene organization among prokaryotes and eukaryotes.
Cell. 2002 Aug 23;110(4):407-13.
Fedorova L, Fedorov A.
Introns in gene evolution.
Genetica. 2003 Jul;118(2-3):123-31.
Konarska MM, Query CC.
Insights into the mechanisms of splicing: more lessons from the ribosome.
Genes Dev. 2005 Oct 1;19(19):2255-60.
Aigner A.
Gene silencing through RNA interference (RNAi) in vivo: strategies based on the direct application of siRNAs.
J Biotechnol. 2006 Jun 25;124(1):12-25.
Brookfield JF, Johnson LJ.
The evolution of mobile DNAs: when will transposons create phylogenies that look as if there is a master gene?
Genetics. 2006 Jun;173(2):1115-23.
Murphy WJ, Stanyon R, O'Brien SJ.
Evolution of mammalian genome organization inferred from comparative gene mapping.
Genome Biol. 2001;2(6).
Supporting videos:
A History of Research on Genetics
55 minutes, English
DNA - Secret of Photo 51 (NOVA)
55 minutes, English
DNA Packaging
3 minutes, English.
TED -Drew Berry: Animations of unseeable biology
9 minutes, English
DNA Replication
21 minutes, English.
DNA Structure and Replication: Crash Course Biology #10
12 minutes, English.
Horizontal Gene Transfer in Prokaryotes
22 minutes, English.
Richard McIntosh Part 1: Preparing for Cell Division
29 minutes, English
Richard McIntosh Part 2: Understanding Mitosis
39 minutes, English
Richard McIntosh Part 3: Microtubule Depolymerization
41 minutes, English
Transcription and Translation
4 minutes, English
Translation: Protein Synthesis
3 minutes, English
Inner Life of the Cell
7 minutes, English
Site version 6.0, last updated September 14, 2023
