| Topic 1. History of Molecular Biology (Oct 18, 2024 v1)
Introducing genomes, history of molecular biology and genome projects. Brief history of human disease genetics (Front Genet. 2021) Oswald Avery: Pioneer of Bacterial Vaccines (Cureus. 2024) |
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| Topic 2. Nucleic acid biochemistry (Oct 21, 2024 v1)
DNA chemistry, molecular structure and conformation, prokaryote and eukaryote genomic ogranization. |
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| Topic 3. Genomes (Nov 21, 2024 v1)
A presentation exploring the structure, function, and evolution of viral and bacterial genomes, highlighting key molecular techniques and their applications in understanding genetic information and its role in biological systems, plasmids, viroids and prions (Pdf). Thermophiles Genome Organization (Microbes Environ. 2024) Whole Genome Sequencing Applications (Microbes Environ. 2024) Ancient Viral Genomes and Human History (Annu Rev Virol. 2023) A Brief History of Plasmids (EcoSal Plus. 2022) Synthetic chromosomes, genomes, viruses, and cells (Cell. 2022) Viroid Replication, Movement, and Host Factors (Microorganisms. 2024) |
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| Topic 4. Genomic compaction in virus and prokaryotes (Nov 21, 2024 v1)
A presentation delving into the mechanisms of DNA packaging in prokaryotes and eukaryotes, and the relationship between genomic organization and function (Pdf). Spatiotemporal Coupling of DNA Supercoiling (Biomolecules. 2022) Evolution of DNA supercoiling (Protein Sci. 2021) Mechanisms for Chromosome Segregation in Bacteria (Front Microbiol. 2021) |
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| Topic 5. Genomic compaction in euokaryotes (Nov 21, 2024 v1)
A presentation delving into the mechanisms of DNA packaging, chromatin structure in eukaryotes, and the relationship between genomic organization and function (Pdf). The chromosome folding problem (Cell. 2024) X-chromosome architecture in mammals (Curr Opin Genet Dev. 2024) Genome organization across scales (Biochem Soc Trans. 2024) Chromatin 3C to Live-Cell Imaging (Chem Biomed Imaging. 2024) |
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| Topic 6. The Nucleosome and Epigenetics (Nov 21, 2024 v1)
A presentation on the nucleosome will examine its structure, assembly, and role in DNA packaging, as well as its critical functions in regulating gene expression and chromatin dynamics (Pdf). Nucleosome Structure and Dynamics (Front Mol Biosci. 2022) Nucleosome Structures from Highly Divergent Histones (Epigenomes. 2022) Epigenetic Code & 3D Genome Landscape (Genes. 2022) Epigenetics and the enchantment of the arts (Environ Epigenet. 2024) Epigenetics Fundamentals and Biomedical Implications (Int J Mol Sci. 2024 |
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| Topic 7. Genes and genomic organization (Nov 14, 2024 v1)
A presentation on gene organization in prokaryotes and eukaryotes will compare their genomic architectures, including operons, introns, exons, regulatory sequences, and the structural and functional implications of these differences (pdf). Shared strategies in gene organization among pro/eukaryotes (Cell. 2002) |
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| Topic 8. Mutagenesis, DNA repair and repair diseases (Nov 21, 2024 v2)
This presentation delves into the mechanisms of mutagenesis, DNA repair, the significance of genetic polymorphisms, the impact of single nucleotide polymorphisms (SNPs) on genetic variation and disease and DNA repair machinery defficiency diseases (Pdf). UV mutagenesis. (J Radiat Res. 2011) Transcription-associated mutagenesis. (Annu Rev Genet. 2014) Mitochondrial DNA Mutagenesis. (Curr Environ Health Rep. 2021) Ataxia-Telangiectasia (GeneReviews. 2023) Fanconi anemia (Ageing Res Rev. 2017) Werner syndrome (Cell Mol Life Sci. 2001) Cockayne Syndrome (GeneReviews. 2000) Hutchinson-Gilford Progeria Syndrome (Cureus. 2022) Xeroderma Pigmentosum (J Pers Med. 2021) |
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| Topic 9. Replicons, Replication and DNA Polymerases (Nov 21, 2024 v2)
This presentation explores the molecular mechanisms of DNA replication in prokaryotes and eukaryotes, highlighting the structure and regulation of replicons, the roles of key DNA polymerases, and their coordination in replication processes (Pdf). Replicon hypothesis revisited (Biochem Biophys Res Commun. 2022) Escherichia coli DNA replication (FEMS Microbiol Rev 2024) Viral Replicon Systems and Biosafety Aspects (Appl Biosaf. 2023) Replication & Transcription of Human Mitochondrial DNA (Annu Rev Biochem. 2024) Eukaryotic Replisome Disassembly at Termination (Biology. 2024) |
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| Topic 10. Prokaryote Transcription (Nov 21, 2024 v1)
This presentation examines the fundamental processes of prokaryotic transcription, including the structure and function of RNA polymerase, promoter recognition, transcription initiation, elongation, termination, and regulatory mechanisms (Pdf). The Transcriptional Landscape (Biomolecules. 2024) Human B-ZIP proteins (Mol Cell Biol. 2002) homeobox genes & Cambrian explosion (Holland Zoological Letters. 2015) Human B-ZIP proteins (Mol Cell Biol. 2002) |
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| Topic 11. Eukaryote Transcription (Nov 21, 2024 v1)
This presentation explores the complexities of eukaryotic transcription, focusing on RNA polymerases, promoter and enhancer elements, transcription factors, chromatin remodeling, and post-transcriptional regulation (Pdf). RNA Polymerase Subunits (Front Biosci, 2024 ) Global control of RNA polymerase II. (Biochim Biophys. 2024) RNA Polymerase II Transcription (Biomolecules. 2024) |
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| Topic 12. mRNA, tRNA, rRNA and Alternative Splicing (Nov 21, 2024 v1)
This presentation explores the roles and processing of mRNA, tRNA, and rRNA in gene expression, with a detailed focus on the mechanisms and regulation of RNA splicing in prokaryotic and eukaryotic cells. (Pdf). Structure in regulatory RNA elements (Biosci Rep. 2024) RNA in axons, dendrites and synapses (Front Mol Neurosci. 2024) Role of RNA structure in eukaryotes. (Curr Opin Struct Biol. 2024) RNA exon editing (Mol Ther Nucleic Acids. 2024) |
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| Topic 13. The Genetic Code (Nov 21, 2024 v1)
Codons and amino acids, redundancy, wobbles, aminoacid nomenclature, alternative codes and biotechnological applications. Genetic code expansion (Protein Cell. 2024) Evolution of the genetic code (Transcription. 2021) |
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| Topic 14. Prokaryote and Eukaryote Translation (Nov 21, 2024 v1)
This presentation compares the molecular mechanisms of translation in prokaryotes and eukaryotes, highlighting the roles of ribosomes, tRNA, translation factors, and regulatory processes in protein synthesis, ribosome sites, initiation, elongation and termination factors, Kozak consensus and Shine-Dalgarno sites (Pdf). Ribosome-Targeting Antibiotics (Annu Rev Biochem. 2018) |
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| Topic 15. Protein Localization (Nov 21, 2024 v1)
This presentation compares the molecular mechanisms of translation in prokaryotes and eukaryotes, highlighting the roles of ribosomes, tRNA, translation factors, and regulatory processes in protein synthesis, ribosome sites, initiation, elongation and termination factors, Kozak consensus and Shine-Dalgarno sites (Pdf). protein localization cues in bacteria (Curr Opin Microbiol. 2017) Mechanisms Regulating Protein Localization (Traffic. 2015) |
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| Topic 16. Chaperones (Nov 21, 2024 v1)
This presentation examines the similarities and differences in prokaryotic and eukaryotic chaperone systems, focusing on their roles in protein folding, stress response, and maintaining proteome stability (Pdf). Molecular chaperones & tumor suppression. (Oncotarget. 2024) |
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| Topic 17. RNA interference, miRNA and siRNA (Nov 21, 2024 v1)
Discovery, mechanism, siRNA, miRNA, RISC complex, gene silencing, therapeutic applications, challenges, and future directions |
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| Topic 18. Transposable elements (Nov 21, 2024 v2)
A presentation on transposable elements will explore their structure and mobility mechanisms, with a focus on retrotransposons, endogenous retroviral sequences, and Alu repeats, highlighting their roles in genome evolution, regulation, and diversity (Pdf). |
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| Topic 19. Pharmacogenetics and Pharmacogenomics (Nov 21, 2024 v2)
A presentation on transposable elements will explore their structure and mobility mechanisms, with a focus on retrotransposons, endogenous retroviral sequences, and Alu repeats, highlighting their roles in genome evolution, regulation, and diversity (Pdf). Pharmacogenetics to pharmaco-omics (HGG Adv. 2022) Pharmacogenetics Into Practice (Clin Pharmacol Ther. 2021) |
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