Syllabus
| Topic 1. History of Molecular Biology (Oct 18, 2024 v1)
Introducing genomes, history of molecular biology and genome projects. |
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| Topic 2. Nucleic acid biochemistry (Oct 21, 2024 v1)
DNA chemistry, molecular structure and conformation, prokaryote and eukaryote genomic ogranization. |
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| Topic 3. Genomes (Nov 21, 2024 v1)
A presentation exploring the structure, function, and evolution of viral and bacterial genomes, highlighting key molecular techniques and their applications in understanding genetic information and its role in biological systems, plasmids, viroids and prions (Pdf). |
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| Topic 4. Genomic compaction in virus and prokaryotes (Nov 21, 2024 v1)
A presentation delving into the mechanisms of DNA packaging in prokaryotes and eukaryotes, and the relationship between genomic organization and function (Pdf). |
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| Topic 5. Genomic compaction in euokaryotes (Nov 21, 2024 v1)
A presentation delving into the mechanisms of DNA packaging, chromatin structure in eukaryotes, and the relationship between genomic organization and function (Pdf). |
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| Topic 6. The Nucleosome and Epigenetics (Nov 21, 2024 v1)
A presentation on the nucleosome will examine its structure, assembly, and role in DNA packaging, as well as its critical functions in regulating gene expression and chromatin dynamics (Pdf). |
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| Topic 7. Genes and genomic organization (Nov 14, 2024 v1)
A presentation on gene organization in prokaryotes and eukaryotes will compare their genomic architectures, including operons, introns, exons, regulatory sequences, and the structural and functional implications of these differences (pdf). |
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| Topic 8. Mutagenesis, DNA repair and repair diseases (Oct 09, 2025 v2)
This presentation delves into the mechanisms of mutagenesis, DNA repair, the significance of genetic polymorphisms, the impact of single nucleotide polymorphisms (SNPs) on genetic variation and disease and DNA repair machinery defficiency diseases (Pdf). |
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| Topic 9. Replicons, Replication and DNA Polymerases (Oct 07, 2025 v2)
This presentation explores the molecular mechanisms of DNA replication in prokaryotes and eukaryotes, highlighting the structure and regulation of replicons, the roles of key DNA polymerases, and their coordination in replication processes (Pdf). |
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| Topic 10. Transcription in prokaryotes and eukaryotes (Oct 07, 2025 v2)
This presentation examines the fundamental processes of both prokaryote and eukaryote transcription, including the structure and function of RNA polymerase, promoter recognition, transcription initiation, elongation, termination, and regulatory mechanisms (Pdf). |
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| Topic 11. mRNA, tRNA, rRNA and Alternative Splicing (Oct 09, 2025 v2)
This presentation explores the roles and processing of mRNA, tRNA, and rRNA in gene expression, with a detailed focus on the mechanisms and regulation of RNA splicing in prokaryotic and eukaryotic cells. (Pdf). |
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| Topic 12. The Genetic Code (Oct 09, 2025 v2)
Codons and amino acids, redundancy, wobbles, aminoacid nomenclature, alternative codes and biotechnological applications. |
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| Topic 13. Prokaryote and Eukaryote Translation (Oct 09, 2025 v2)
This presentation compares the molecular mechanisms of translation in prokaryotes and eukaryotes, highlighting the roles of ribosomes, tRNA, translation factors, and regulatory processes in protein synthesis, ribosome sites, initiation, elongation and termination factors, Kozak consensus and Shine-Dalgarno sites (Pdf). |
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| Topic 14. Protein Localization (Oct 09, 2025 v2)
This presentation compares the molecular mechanisms of translation in prokaryotes and eukaryotes, highlighting the roles of ribosomes, tRNA, translation factors, and regulatory processes in protein synthesis, ribosome sites, initiation, elongation and termination factors, Kozak consensus and Shine-Dalgarno sites (Pdf). |
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| Topic 15. Chaperones (Oct 09, 2025 v2)
This presentation examines the similarities and differences in prokaryotic and eukaryotic chaperone systems, focusing on their roles in protein folding, stress response, and maintaining proteome stability (Pdf). |
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| Topic 16. RNA interference, miRNA and siRNA (Oct 12, 2025 v2)
Discovery, mechanism, siRNA, miRNA, RISC complex, gene silencing, therapeutic applications, challenges, and future directions |
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| Topic 17. Transposable elements (Oct 12, 2025 v2)
A presentation on transposable elements will explore their structure and mobility mechanisms, with a focus on retrotransposons, endogenous retroviral sequences, and Alu repeats, highlighting their roles in genome evolution, regulation, and diversity (Pdf). |
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| Topic 18. Pharmacogenetics and Pharmacogenomics (Oct 12, 2025 v2)
A presentation on transposable elements will explore their structure and mobility mechanisms, with a focus on retrotransposons, endogenous retroviral sequences, and Alu repeats, highlighting their roles in genome evolution, regulation, and diversity (Pdf). |
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